You must first purchase the necessary texts to learn how to inscribe. Then you must buy supplies. Scribing pens enable you to write the runes onto equipment and slots are where the runes are placed on the equipment. These things can be found on the items pages. You may only inscript equipment. Each piece of equipment may only have one level 1 rune and one level 2 rune inscribed into it. Once inscribed you change the items name. You may also inscribe other people's equipment as long as you are in the same location as them. If you are going to charge for inscriptions you must due so via the auction house so it can be accounted for.

To inscribe a rune into an item it takes 1 week and holds up a building slot.

For example:

Weighted Gloves of Fire ( level 1 rune)

or

Weighted Gloves of Fire and Rage (level 1 rune, level 2 rune)

Fire - Increases training by +3 strength per week.
Wind - Increases training by + 3 speed.
Water - Increases training by +3 vitality
Earth - Increases training by +3 toughness
Spirit - Increases training by +3 stamina

*note* If followed by a level 2 rune and item would say Super Weighted Clothing of Fire and Rage. The name of the level 2 rune comes second.

Rage - +50 strength in battle.
Grace - +50 speed in battle.
Health - +50 vitality in battle.
Consitution - +50 toughness in battle.
Enduance - +50 stamina in battle.
Knowledge - +5 intelligence
Willpower - +5 determination
Personality - +5 charisma
Combat - +10 exp to battles and +5 exp to spars.
Energy - Ki attacks do 1% more damage
Might - Phyiscal attacks do 1% more damage.
Training - All training adds an extra +1 to stats.
Technique - +1SP to master training per week.
Restoration - Increases the effects of healing items and the ability Heal by 10%.
Fortune - Increase zeni from side jobs by 50.